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KMID : 1149219970050010169
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Korean Journal of Oriental Medical Prescription
1997 Volume.5 No. 1 p.169 ~ p.178
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The effect of Asparagi Tuber on Anti-cancer and Immunocytes
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Jung Hyun-Woo
Cho Young-Lim
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Abstract
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To investigate effect of water extract of Asparagi Tuber(天門冬) on human cancer cell-lines and immunocytes, this research estimated proliferation of A431 cell line, KHOS-NP cell line, mouse thymocytes and mouse splenocytes, Nitric Oxide(NO) from macrophage, apoptosis and subpopulation of the mouse thymocytes. The result were obtained as follows ; 1. Asparagi Tuber inhibited the proliferation of A431 cell line. 2. Asparagi Tuber inhibited the proliferation of KHOS-NP cell line. 3. Asparagi Tuber accelerated the proliferation of mouse thymocytes. 4. Asparagi Tuber inhibited the proliferation of mouse splenocytes. 5. Asparagi Tuber 100ug/ml inhibited the production of NO from macrophages in vitro, being compared NPS+IFN treated group. 6. Asparagi Tuber inhibited the production of NO from macrophages in vivo, being compared LPS+IFN treated group. 7. Asparagi Tuber accelerated the induction of apoptosis of the mouse thymocytes. 8. In subpopulation Asparagi Tuber increased TH of the mouse thymocytes, but decreased Tc/Ts of the mouse thymocytes.
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KEYWORD
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AsparagiTuber, A431cell, KHOS-NPcell, immunocytes, NitiricOxide(NO), apoptosis, subpopulation, THcell, Tc/TScell
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